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Article

ALS-linked TDP-43 mutations interfere with the recruitment of RNA recognition motifs to G-quadruplex RNA.

Scientific reports - 12 Apr 2023

Ishiguro Akira, Ishihama Akira

Abstract excerpt

TDP-43 is a major pathological protein in sporadic and familial amyotrophic lateral sclerosis (ALS) and mediates mRNA fate. TDP-43 dysfunction leads to causes progressive degeneration of motor neurons, the details of which remain elusive. Elucidation of the molecular mechanisms of RNA binding could enhance our understanding of this devastating disease. We observed the involvement of the glycine-rich (GR) region...

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Identifiers

PMID: 37046025
DOI: 10.1038/s41598-023-33172-5
PMCID: PMC10097714

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