Article

DCHS1 Modulates Forebrain Proportions in Modern Humans via a Glycosylation Change

2025-05-14

Abstract excerpt

Comparative anatomical studies of primates and extinct hominins, including Neanderthals, show that the modern human brain is characterised by a disproportionately enlarged neocortex relative to the striatum. To explore the molecular basis of this difference, we screened for missense mutations that are unique to modern humans and occur at high frequency and that alter post-translational sites. One such mutation was...

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Literature Corpus work: ba5c6af0-ab01-5126-b002-4307f44f5b8e
DOI: 10.1101/2025.05.14.654031

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