Article

The Structural History of Eukarya

2026-02-06

Abstract excerpt

Comparative genomics has traditionally relied on sequence-based markers, yet the global evolutionary landscape of protein architecture remains largely unexplored. We present the Structural History of Eukarya (SHE), a phylogeny derived from all-vs-all structural comparisons of 1,542 eukaryotic proteomes, encompassing nearly 300 trillion protein-protein alignments. This proteome-scale analysis reveals a bipartite mo...

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Literature Corpus work: ba5b8a44-2a4f-54cc-af48-1ff382c24e76
DOI: 10.64898/2026.02.04.703859

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