Article
The modular nature of protein evolution: domain rearrangement rates across eukaryotic life.
BMC evolutionary biology - 14 Feb 2020
Dohmen Elias, Klasberg Steffen, Bornberg-Bauer Erich, Perrey Sören, Kemena Carsten
Abstract excerpt
BACKGROUND: Modularity is important for evolutionary innovation. The recombination of existing units to form larger complexes with new functionalities spares the need to create novel elements from scratch. In proteins, this principle can be observed at the level of protein domains, functional subunits which are regularly rearranged to acquire new functions. RESULTS: In this study we analyse the mechanisms leading...
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