Article
Reductive evolution of proteomes and protein structures.
Proceedings of the National Academy of Sciences of the United States of America - 19 Jul 2011
Wang Minglei, Kurland Charles G, Caetano-Anollés Gustavo
Abstract excerpt
The lengths of orthologous protein families in Eukarya are almost double the lengths found in Bacteria and Archaea. Here we examine protein structures in 745 genomes and show that protein length differences between superkingdoms arise as much shorter prokaryotic nondomain linker sequences. Eukaryotic, bacterial, and archaeal linkers are 250, 86, and 73 aa residues in length, respectively, whereas folded domain...
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