Article

The Deubiquitinating Enzyme Otub2 Modulates Pancreatic Beta-Cells Function and Survival

2024-10-01

Abstract excerpt

We have previously shown that otubain 2 (OTUB2), a deubiquitinating enzyme, inhibits caspase-3/7 activity in primary human islets; promotes insulin secretion and inhibits cytokine-induced nuclear factor-κB (NFκB) activity. In the present work we show that overexpression of Otub2 in MIN6 cells inhibits NFκB activity and the expression of its target genes MCP-1 and iNOS. Consequently, both the basal and the cytokine...

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Literature Corpus work: ba23361c-c41d-50e7-ae6a-90433396aa2e
DOI: 10.1101/2024.09.30.615641

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