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Article

Casein kinase 2 (CK2) phosphorylates the deubiquitylase OTUB1 at Ser16 to trigger its nuclear localization.

Science signaling - 14 Apr 2015

Herhaus Lina, Perez-Oliva Ana B, Cozza Giorgio, Gourlay Robert, Weidlich Simone, Campbell David G, Pinna Lorenzo A, Sapkota Gopal P

Abstract excerpt

The deubiquitylating enzyme OTUB1 is present in all tissues and targets many substrates, in both the cytosol and nucleus. We found that casein kinase 2 (CK2) phosphorylated OTUB1 at Ser(16) to promote its nuclear accumulation in cells. Pharmacological inhibition or genetic ablation of CK2 blocked the phosphorylation of OTUB1 at Ser(16), causing its nuclear exclusion in various cell types. Whereas we detected...

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Identifiers

PMID: 25872870
DOI: 10.1126/scisignal.aaa0441
PMCID: PMC4421874

Genes

OTUB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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