Article

Leukemic Cells Manipulate MSCs Bioelectrical Signals to Reshape the Bone Marrow Niche

2025-03-13

Abstract excerpt

<h4>ABSTRACT</h4> Mesenchymal stromal cells (MSCs) are key components of the tumor microenvironment (TME), influencing leukemia progression through poorly understood mechanisms. We investigated the bioelectrical properties of MSCs derived from pediatric AML patients (AML-MSCs) and identified a significant depolarization of their resting membrane potential (V mem , −14.7mV) compared to healthy MSCs (h-MSCs, −28.5...

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Literature Corpus work: ba14c128-ef71-55ae-9920-52a6af6f7ac3
DOI: 10.1101/2025.03.10.642319

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