Article

Human mitochondrial transfer modeling reveals biased delivery from mesenchymal-to-hematopoietic stem cells

2025-01-06

Abstract excerpt

Within the bone marrow (BM), the intercellular communication between hematopoietic stem and progenitor cells (HSPCs) and mesenchymal stem/stromal cells (MSCs) is critical for the life-long maintenance of functional hematopoiesis. In recent years, the transfer of mitochondria between MSCs and HSPCs has emerged as a key aspect of this communication, occurring both in stress and homeostatic conditions. In human, the...

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Literature Corpus work: bb9cfa75-f674-5cd2-8746-7ca192304cc1
DOI: 10.1101/2025.01.06.631461

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