Article
Directed migration of human bone marrow mesenchymal stem cells in a physiological direct current electric field.
European cells & materials - 29 Nov 2011
Zhao Zhiqiang, Watt Carolyn, Karystinou Alexandra, Roelofs Anke J, McCaig Colin D, Gibson Iain R, De Bari Cosimo
Abstract excerpt
At sites of bone fracture, naturally-occurring electric fields (EFs) exist during healing and may guide cell migration. In this study, we investigated whether EFs could direct the migration of bone marrow mesenchymal stem cells (BM-MSCs), which are known to be key players in bone formation. Human BM-MSCs were cultured in direct current EFs of 10 to 600 mV/mm. Using time-lapse microscopy, we demonstrated that an...
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