Article

Herpes simplex virus pUL56 abolishes neuronal activity by removing voltage-gated ion channels from the plasma membrane

2026-04-13

Abstract excerpt

Herpes simplex virus 1 (HSV-1) infections of the central nervous system cause encephalitis and are associated with increased risk of neurodegeneration, yet the molecular consequences of lytic infection in human neurones remain incompletely defined. We map the transcriptomic, proteomic and surface-proteome changes induced by HSV-1 across the lytic infection cycle in human iPSC-derived cortical glutamatergic neurone...

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Literature Corpus work: b9f34448-7e68-5d5b-b534-799204d164cb
DOI: 10.64898/2026.04.10.717620

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