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Article

The Torsin Activator LULL1 Is Required for Efficient Growth of Herpes Simplex Virus 1

4 Jun 2015

Abstract excerpt

UNLABELLED: TorsinA is a membrane-tethered AAA+ ATPase implicated in nuclear envelope dynamics as well as the nuclear egress of herpes simplex virus 1 (HSV-1). The activity of TorsinA and the related ATPase TorsinB strictly depends on LAP1 and LULL1, type II transmembrane proteins that are integral parts of the Torsin/cofactor AAA ring, forming a composite, membrane-spanning assembly. Here, we use...

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PMID: 26041288
DOI: 10.1128/jvi.01143-15

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