Article

scLASER: a robust framework for simulating and detecting time-dependent single-cell dynamics in longitudinal studies

2026-05-07

Abstract excerpt

Longitudinal single-cell clinical studies enable tracking within-individual cellular dynamics, but methods for modeling temporal phenotypic changes and estimating power remain limited. We present scLASER, a framework detecting time-dependent cellular neighborhood dynamics and simulating longitudinal single-cell datasets for power estimation. Across benchmark experiments, scLASER shows consistently higher sensitivi...

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Literature Corpus work: b9af5074-340a-5bea-9970-be91d81401e5
DOI: 10.64898/2026.05.04.722712

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