Article

FAP-intrinsic Hedgehog signaling controls intramuscular adipogenesis, fibrosis, and myofiber regeneration

2026-06-02

Abstract excerpt

<h4>Summary</h4> Fibro/adipogenic progenitors (FAPs) are multipotent stromal cells that support myofiber regeneration, but can also give rise to intramuscular adipose tissue (IMAT) and fibrotic scar tissue. While the Hedgehog pathway suppresses FAP adipogenesis and promotes myofiber repair through ligand Desert Hedgehog, the key cell type that senses this signal has remained unclear. Here, we demonstrate through...

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Literature Corpus work: b9a4a1f9-2398-58a8-8c04-21125ce238fc
DOI: 10.64898/2026.05.29.727896

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