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Multi-Layered Transcriptomic Holistic Analyses Reveal an Immunological Overlap between COVID-19 and Hemophagocytic Lymphohistiocytosis Associated with Disease Severity

2021-10-18

Abstract excerpt

Clinical and hyperinflammatory overlap between COVID-19 and hemophagocytic lymphohistiocytosis (HLH) has been reported. However, the underlying mechanisms are unclear. Here we show that COVID-19 and HLH have an overlap of signaling pathways and gene signatures commonly dysregulated, which were defined by investigating the transcriptomes of 1253 subjects (controls, COVID-19, and HLH patients) using microarray, bulk...

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Literature Corpus work: b949a8d9-6e6d-5a8b-8c47-89cbad837aff
DOI: 10.2139/ssrn.3945023

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Multi-Layered Transcriptomic Holistic Analyses Reveal an Immunological Overlap between COVID-19 and Hemophagocytic Lymphohistiocytosis Associated with Disease SeverityDOI 10.2139/ssrn.3945023Read

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