Article
Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients.
Genome medicine - 13 Jan 2021
Aschenbrenner Anna C, Mouktaroudi Maria, Krämer Benjamin, Oestreich Marie, Antonakos Nikolaos, Nuesch-Germano Melanie, Gkizeli Konstantina, Bonaguro Lorenzo, Reusch Nico, Baßler Kevin, Saridaki Maria, Knoll Rainer, Pecht Tal, Kapellos Theodore S, Doulou Sarandia, Kröger Charlotte, Herbert Miriam, Holsten Lisa, Horne Arik, Gemünd Ioanna D, Rovina Nikoletta, Agrawal Shobhit, Dahm Kilian, van Uelft Martina, Drews Anna, Lenkeit Lena, Bruse Niklas, Gerretsen Jelle, Gierlich Jannik, Becker Matthias, Händler Kristian, Kraut Michael, Theis Heidi, Mengiste Simachew, De Domenico Elena, Schulte-Schrepping Jonas, Seep Lea, Raabe Jan, Hoffmeister Christoph, ToVinh Michael, Keitel Verena, Rieke Gereon, Talevi Valentina, Skowasch Dirk, Aziz N Ahmad, Pickkers Peter, van de Veerdonk Frank L, Netea Mihai G, Schultze Joachim L, Kox Matthijs, Breteler Monique M B, Nattermann Jacob, Koutsoukou Antonia, Giamarellos-Bourboulis Evangelos J, Ulas Thomas
Abstract excerpt
BACKGROUND: The SARS-CoV-2 pandemic is currently leading to increasing numbers of COVID-19 patients all over the world. Clinical presentations range from asymptomatic, mild respiratory tract infection, to severe cases with acute respiratory distress syndrome, respiratory failure, and death. Reports on a dysregulated immune system in the severe cases call for a better characterization and understanding of the...
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