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Validation of novel catechol derivatives as potent Escherichia coli MetAP inhibitors using Molecular Docking and Molecular Dynamics Simulation

2023-01-05

Abstract excerpt

Urinary tract infections (UTIs) are the most common form of nosocomial infection primarily caused by Escherichia coli . Complicated UTIs carries higher risk of treatment failure, recurrent infections and increased morbidity. Methionine aminopeptidase (MetAP) has got tremendous importance as bacterial drug target due to its role in cell growth and membrane integrity. However, participation of metal chelating residu...

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Literature Corpus work
b8c8c0ce-7846-5b25-83fa-4700c2a0874e
DOI
10.21203/rs.3.rs-2420602/v1
Open publication

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Validation of novel catechol derivatives as potent Escherichia coli MetAP inhibitors using Molecular Docking and Molecular Dynamics SimulationDOI 10.21203/rs.3.rs-2420602/v1
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