The structure of the bacterial iron-catecholate transporter Fiu suggests that it imports substrates via a two-step mechanism.

Abstract excerpt

The ferric iron uptake (Fiu) transporter from Escherichia coli functions in the transport of iron-catecholate complexes across the bacterial outer membrane, providing the bacterium with iron, which is essential for growth. Recently it has become clear that Fiu also represents a liability for E. coli because its activity allows import of antimicrobial compounds that mimic catecholate. This inadvertent import...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Catechols
• Share to Crystallography, X-Ray
• Share to Genetic Complementation Test