Article

Loss of CYP2D6 sensitizes hepatocellular carcinomas and neuroblastomas to talazoparib

2023-08-21

Abstract excerpt

<title>Abstract</title> <p>Cancers often have reduced allelic diversity because of loss of heterozygosity (LOH). Therefore, tumors arising in patients heterozygous for a functional and a loss-of-functon(LoF) allele may lose the functional allele, rendering them sensitive to allele-specific therapies. To discover such alleles, we mined the 1000 Genomes dataset for SNVs causing protein truncation through base subst...

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Literature Corpus work: 91cea96b-83a1-57c9-83ff-5b11bec52061
DOI: 10.21203/rs.3.rs-3254750/v1

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