Functional Analysis of Antigen 43 in Uropathogenic<i>Escherichia coli</i>Reveals a Role in Long-Term Persistence in the Urinary Tract

Abstract excerpt

Escherichia coli is the primary cause of urinary tract infection (UTI) in the developed world. The major factors associated with the virulence of uropathogenic E. coli (UPEC) are fimbrial adhesins, which mediate specific attachment to host receptors and trigger innate host responses. Another group of adhesins is represented by the autotransporter subgroup of proteins. The best characterized of these proteins,...

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