Article
Secretion of a bacterial virulence factor is driven by the folding of a C-terminal segment.
Proceedings of the National Academy of Sciences of the United States of America - 12 Oct 2010
Peterson Janine H, Tian Pu, Ieva Raffaele, Dautin Nathalie, Bernstein Harris D
Abstract excerpt
Autotransporters are bacterial virulence factors consisting of an N-terminal "passenger domain" that is secreted in a C- to-N-terminal direction and a C-terminal "β domain" that resides in the outer membrane (OM). Although passenger domain secretion does not appear to use ATP, the energy source for this reaction is unknown. Here, we show that efficient secretion of the passenger domain of the Escherichia coli...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.