Article

Dexmedetomidine modulates macrophage polarization by inhibiting ferroptosis to exert protective effects on intestinal barrier function in sepsis

2025-06-29

Abstract excerpt

<title>Abstract</title> <p>The intestine is believed to play a pivotal role in the onset and progression of sepsis, serving as the driving force behind multiple organ dysfunction syndrome. The polarization state of macrophages is pivotal in the intestinal barrier dysfunction associated with sepsis. M1 macrophages initiate the degradation of barrier-sealing molecules, increasing intestinal barrier permeability. St...

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Literature Corpus work: b8bcc491-4230-53e3-aadd-407c47393453
DOI: 10.21203/rs.3.rs-6742785/v1

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