Low-dose Olaparib improves septic cardiac function by reducing ferroptosis via accelerated mitophagy flux

Abstract excerpt

Sepsis is a dysregulated response to infection that can result in life-threatening organ failure, and septic cardiomyopathy is a serious complication involving ferroptosis. Olaparib, a classic targeted drug used in oncology, has demonstrated potential protective effects against sepsis. However, the exact mechanisms underlying its action remain to be elucidated. In our study, we meticulously screened ferroptosis...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Ferroptosis and cancer prognosis
• Share to PARP inhibition in cancer therapy
• Share to RNA modifications and cancer