Article

Myoglobin leaching into the serum of IDA mice is driven by the high activation of sGC under anemic conditions which induces myoglobin expression

2025-10-04

Abstract excerpt

<h4>ABSTRACT</h4> Our study reveals that status of the sGC heterodimer or its subsequent activation aligns with active erythropoiesis, and this heterodimer also correlates with the expression of myoglobin (Mb) or HO1. In this study we found that Mb expression which is driven by iron restriction and high sGC activation in iron deficiency anemia (IDA) leaches out more into the serum relative to non-anemic WTs. Tiss...

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Literature Corpus work: b8a8a6d3-8fb6-5ee4-b2a7-42b693575408
DOI: 10.1101/2025.10.03.680120

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