Back to search

Article

CD33 <sup>KO</sup> -CD33-mesothelin loop CAR design avoids fratricide and improves efficacy of iNK cells against acute myeloid leukemia

2025-01-26

Abstract excerpt

Acute myeloid leukemia (AML) patients are often older, which brings challenges of endurance and persistent efficacy of autologous CAR-T cell therapies. Allogenic CAR-NK cell therapies may offer reduced toxicities and enhanced anti-leukemic potential against AML. In this study, we designed a novel CD33-mesothelin loop CAR (Loop CAR) and evaluated its anti-tumor efficacy in human umbilical cord blood-derived NK (UCB...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
f81d25c8-9901-5da4-ad37-12c3c32da804
DOI
10.1101/2025.01.23.634500
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
CD33 <sup>KO</sup> -CD33-mesothelin loop CAR design avoids fratricide and improves efficacy of iNK cells against acute myeloid leukemiaDOI 10.1101/2025.01.23.634500
Engineering CAR-NK cells targeting CD33 with concomitant extracellular secretion of anti-CD16 antibody revealed superior antitumor effects toward myeloid leukemiaSemantic proximity
In-depth comparative characterization identifies scalable CD123-CAR-NK cells as promising strategy to combat AMLSemantic proximity
CD33 Epitope Editing Unlocks UM171-Expanded Cord Blood Grafts for AML ImmunotherapySemantic proximity
Efficient generation of CAR NK cells from human umbilical cord blood CD34 <sup>+</sup> stem and progenitors for democratizing affordable immunotherapySemantic proximity
Anti-TIM3 chimeric antigen receptor-natural killer cells from engineered induced pluripotent stem cells effectively target acute myeloid leukemia cellsSemantic proximity
Engineered CRO-CD7 CAR-NK cells derived from pluripotent stem cells avoid fratricide and efficiently suppress human T-cell malignanciesSemantic proximity
Adoptive NK cell therapy in AML: progress and challengesSemantic proximity
Generation of dual-attribute iTNK cells from hPSCs for cancer immunotherapySemantic proximity
Engineered CRO-CD7 CAR-NK cells derived from pluripotent stem cells avoid fratricide and efficiently suppress human T-cell malignanciesSemantic proximity
CAR-NK cells for gastrointestinal cancer immunotherapy: from bench to bedsideSemantic proximity
Optimization of universal allogeneic CAR-T cells combining CRISPR and transposon-based technologies for treatment of acute myeloid leukemiaSemantic proximity
Hypoimmunogenic CD19 CAR-NK cells derived from embryonic stem cells suppress the progression of human B-cell malignancies in xenograft animalsSemantic proximity
Select a neighboring publication to make it the new centre.