Article

Upregulation of HOXA3 by Isoform-Specific Wilms Tumor 1 Drives Chemotherapy Resistance in Acute Myeloid Leukemia

2023-09-20

Abstract excerpt

<title>Abstract</title> <p>Upregulation of the Wilms' Tumor 1 (WT1) gene is common in acute myeloid leukemia and is associated with poor prognosis. WT1 produces 12 primary transcripts through different translation initiation sites and alternative splicing. We found that overexpression of short WT1 transcripts lacking exon 5 with and without the KTS motif (sWT1+/- and sWT1-/-) led to reduced cell growth. However,...

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Literature Corpus work: b7ee0e57-cf30-5b68-b8af-a5209fdccc0a
DOI: 10.21203/rs.3.rs-3290666/v1

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