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DNA methylation analysis using RUNX1-mutated cells reveals association of FLI1 to familial platelet disorder with associated myeloid malignancies caused by a mutation in the transactivation domain of RUNX1

2024-02-20

Abstract excerpt

<h4>Background: </h4> Familial platelet disorder with associated myeloid malignancies (FPDMM) is an autosomal dominant disease caused by heterozygous germline mutations in RUNX1 . It is characterized by thrombocytopenia with platelet dysfunction and a high risk of hematological malignancy development. Although FPDMM is a precursor condition for diseases involving abnormal DNA methylation, such as myelodysplastic s...

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Literature Corpus work
b7ddaf47-d50b-5885-87ab-b8451e93a33a
DOI
10.21203/rs.3.rs-3939381/v1
Open publication

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DNA methylation analysis using RUNX1-mutated cells reveals association of FLI1 to familial platelet disorder with associated myeloid malignancies caused by a mutation in the transactivation domain of RUNX1DOI 10.21203/rs.3.rs-3939381/v1
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