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Article

FLI1 is associated with regulation of DNA methylation and megakaryocytic differentiation in FPDMM caused by a RUNX1 transactivation domain mutation.

Scientific reports - 18 Jun 2024

Tanaka Yuki, Nakanishi Yuri, Furuhata Erina, Nakada Ken-Ichi, Maruyama Rino, Suzuki Harukazu, Suzuki Takahiro

Abstract excerpt

Familial platelet disorder with associated myeloid malignancies (FPDMM) is an autosomal dominant disease caused by heterozygous germline mutations in RUNX1. It is characterized by thrombocytopenia, platelet dysfunction, and a predisposition to hematological malignancies. Although FPDMM is a precursor for diseases involving abnormal DNA methylation, the DNA methylation status in FPDMM remains unknown, largely due...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38890442
DOI: 10.1038/s41598-024-64829-4
PMCID: PMC11189521

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