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Single-cell RNA sequencing reveals 2D cytokine assay can model atopic dermatitis more accurately than immune-competent 3D setup

2023-05-26

Abstract excerpt

<h4>Background: </h4> Modelling atopic dermatitis (AD) in vitro is paramount to understand the disease pathophysiology and identify novel treatments. Previous studies have shown that the Th2 cytokines IL-4 and IL-13 induce AD-like features in keratinocytes in vitro . However, it has not been systematically researched whether the addition of Th2 cells, their supernatants or a 3D structure are superior to model AD...

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Literature Corpus work: b79edbda-f528-598c-937a-1175c732be8d
DOI: 10.22541/au.168507561.19506037/v1

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