Article

Human-derived NLS enhance the gene transfer efficiency of chitosan

2020-03-15

Abstract excerpt

Nuclear import is considered one of the major limitations for non-viral gene delivery systems and the incorporation of nuclear localization signals (NLS) that mediate nuclear intake can be used as a strategy to enhance internalization of exogenous DNA. In this work, human-derived endogenous NLS peptides based on Insulin Growth Factor Binding Proteins (IGFBP), namely IGFBP-3 and IGFBP-5, were tested for their abili...

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Literature Corpus work: b775bb8f-53df-5a17-9546-a185d4efeb91
DOI: 10.1101/2020.03.13.990390

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