Article

Interaction with C21ORF2 controls the cellular functioning of the NEK1 kinase

2022-08-31

Abstract excerpt

NEK1 is a pleiotropic protein kinase implicated in mitosis, ciliogenesis and DNA repair but little is known about its regulation or targets. Its relevance for human health is underscored by the association of NEK1 mutations with human diseases including axial spondylometaphyseal dyplasia (SMD) and amyotrophic lateral sclerosis (ALS). Mutations in the C21ORF2 gene are associated with a similar pattern of human di...

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Literature Corpus work: b6930a1c-9b27-59c7-bd15-1b5485a8f5f6
DOI: 10.1101/2022.08.31.505651

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