Article

ILA-producing Lacticaseibacillus paracasei NCU-21 exerts anti-acute myeloid leukemia effects by inhibiting the PI3K-AKT pathway

2026-08-18

Abstract excerpt

Cytarabine (Ara-C) remains the cornerstone of induction therapy for acute myeloid leukemia (AML). However, its overall clinical efficacy is suboptimal, and the regimen is frequently accompanied by severe disruption of intestinal homeostasis. Consequently, identifying novel adjunctive therapies to improve treatment outcomes represents a critical clinical need. Gut microbiome profiling in AML mouse models reveals th...

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Literature Corpus work: b643d576-71be-5d09-9bfb-29090a3c82ff
DOI: 10.1186/s13059-026-04225-5

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