Article

COMPARATIVE MODELING OF METHYLENTETRAHYDROFOLATE REDUCTASE (MTHFR) ENZYME AND ITS MUTATIONAL ASSESSMENT: IN SILICO APPROACH

2010-06-30

Abstract excerpt

DNA-synthesis, DNA-repair, and DNA imprinting processes require efficient conversion of homocysteine to methionine. This methylation is catalyzed by methylentetrahydrofolate reductase through reduction of 5,10-methylenetetrahydrofolate into 5-methyltetrahydrofolate. Normal DNA synthesis is considered critical for physiological functions of body. The enzyme is coded by the gene with the symbol MTHFR on chromosome 1...

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Literature Corpus work: b60e1e17-8358-50d2-b806-2f27d2004e36
DOI: 10.9735/0975-3087.2.1.5-9

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