Article
A Computational Approach to Identify the Biophysical and Structural Aspects of Methylenetetrahydrofolate Reductase (MTHFR) Mutations (A222V, E429A, and R594Q) Leading to Schizophrenia.
Advances in protein chemistry and structural biology - 1 Jan 2017
Tanwar Himani, Sneha P, Thirumal Kumar D, Siva R, Walter Charles Emmanuel Jebaraj, George Priya Doss C
Abstract excerpt
The association between depression and methylenetetrahydrofolate reductase (MTHFR) has been continually demonstrated in clinical studies, yet there are sparse resources available to build a relationship between the mutations associated with MTHFR and depression. The common mutations found to be associated with schizophrenia and MTHFR are A222V, E429A, and R594Q. Although abundant research on structural and...
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