Transcriptome Analysis of Circulating microRNAs Associated With Chagas Disease Susceptibility and Chronic Chagas Cardiomyopathy Severity.

doi:10.1093/infdis/jiag021

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Article

Transcriptome Analysis of Circulating microRNAs Associated With Chagas Disease Susceptibility and Chronic Chagas Cardiomyopathy Severity.

The Journal of infectious diseases - 2 Sept 2026

Roma Eric Henrique, Marques-Santos Fabielle, Renzetti Alinne Rangel Dos Santos, Portela Luciana Fernandes, da Costa Filipe Pereira, Hasslocher-Moreno Alejandro Marcel, de Holanda Marcelo Teixeira, Sangenis Luiz Henrique Conde, da Costa Andréa Rodrigues, Lannes-Vieira Joseli, de Araujo-Jorge Tania Cremonini, Ferreira Roberto Rodrigues, Saraiva Roberto Magalhães, Bonecini-Almeida Maria da Glória

Abstract excerpt

BACKGROUND: Chagas disease (ChD), a major public health concern in Latin America, requires better understanding of molecular mechanisms driving disease progression and identification of biomarkers. We investigated circulating microRNAs associated with ChD susceptibility and chronic Chagas cardiomyopathy (CCC) progression. METHODS: In a cross-sectional study of 150 patients with ChD (46 indeterminate, 104 CCC) and...

Read the complete abstract on PubMed

Topics

Humans
Female
Male
Chagas Cardiomyopathy

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Middle Aged

Gene Expression Profiling

Circulating MicroRNA

Cross-Sectional Studies

Biomarkers

Adult

Genetic Predisposition to Disease

MicroRNAs

Severity of Illness Index

Chronic Disease

Disease Progression

Disease Susceptibility

Source

Open in PubMed

Identifiers

PMID: 41574750
DOI: 10.1093/infdis/jiag021

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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