Article

RAF inhibitors activate the integrated stress response by direct activation of GCN2

2024-08-16

Abstract excerpt

Paradoxical RAF activation by chemical RAF inhibitors (RAFi) is a well-understood ‘on-target’ biological and clinical response. In this study, we show that a range of RAFi drive ERK1/2-independent activation of the Unfolded Protein Response (UPR), including expression of ATF4 and CHOP, that required the translation initiation factor eIF2α. RAFi-induced ATF4 and CHOP expression was not reversed by inhibition of PER...

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Literature Corpus work: b6065c5c-06bd-5dab-b68f-7d19241396b5
DOI: 10.1101/2024.08.15.607884

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