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Article

Zebrafish studies identify serotonin receptors mediating antiepileptic activity in Dravet syndrome

1 Jan 2019

Abstract excerpt

Abstract Dravet syndrome is a life-threatening early-onset epilepsy not well controlled by antiepileptic drugs. Drugs that modulate serotonin (5-HT) signalling, including clemizole, locaserin, trazodone and fenfluramine, have recently emerged as potential treatment options for Dravet syndrome. To investigate the serotonin receptors that could moderate this antiepileptic activity, we designed and synthesized 28...

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PMID: 31667472
DOI: 10.1093/braincomms/fcz008

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