Article

A high-throughput drug combination screen identifies an anti-glioma synergism between TH588 and PI3K inhibitors

2020-07-10

Abstract excerpt

<title>Abstract</title> <p>Background: Glioblastoma multiforme (GBM) is the most common and lethal type of primary brain tumor. More than half of GBMs contain mutation(s) of PTEN/PI3K/AKT, making inhibitors targeting the PI3K pathway very attractive for clinical investigation. However, so far, PI3K/AKT/mTOR inhibitors have not achieved satisfactory therapeutic effects in clinical trials of GBM. In this study, we...

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Literature Corpus work: b565abfe-e920-58aa-a8c2-12c29998a4c8
DOI: 10.21203/rs.3.rs-25358/v3

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