Article

Local genetic correlations exist among neurodegenerative and neuropsychiatric diseases

2022-05-31

Abstract excerpt

Genetic correlation ( r g ) between traits can offer valuable insight into underlying shared biological mechanisms. Neurodegenerative diseases overlap neuropathologically and often manifest comorbid neuropsychiatric symptoms. However, global r g analyses show minimal r g among neurodegenerative and neuropsychiatric diseases. Importantly, local r g s can exist in the absence of global relationships. To investig...

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Literature Corpus work: b51e1318-b282-5fdd-951e-35adce6c9a54
DOI: 10.1101/2022.05.30.22275781

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