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Article

Allosteric Binding-Mediated Suppression on Activity of G12D KRAS Recognized via Markov State Model and Communication Pathway.

The journal of physical chemistry. B - 12 Feb 2026

Chen Jianzhong, Wang Jian, Wang Wei, Zhao Lu, Jin Handong, Hu Guodong

Abstract excerpt

The KRAS G12D mutation is one of the most common oncogenic lesions in human tumors, especially in pancreatic ductal adenocarcinoma. The monobodies 12D1 and 12D5 exhibit high selectivity for the G12D mutant of KRAS compared to the wild-type (WT) form. However, the structural and dynamic factors underlying this specificity are still not fully understood. To explore this, we analyzed the transition direction of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41610434
DOI: 10.1021/acs.jpcb.5c07583

Genes

KRAS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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