Article

SARS-CoV-2 Infection Causes Strong mTORC1 Inhibition and Massive Polysome Collapse

2021-05-09

Abstract excerpt

<h4>ABSTRACT</h4> Viruses employ distinct strategies to ensure efficient translation of their mRNAs over the host transcripts. SARS-CoV-2 targets host mRNAs and ribosomes to favor its own protein synthesis. However, the modulation of the key signal pathways that control the host protein translation machinery during SARS-CoV-2 infection has not been sufficiently addressed. Here, by employing an early variant and a...

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Literature Corpus work: b4c436be-c9c2-5b2a-9480-64893559f667
DOI: 10.1101/2021.05.08.443207

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