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Mitochondria and Lipid Defects in Hereditary Progranulin-Related Frontotemporal Dementia.

Cells - 1 Feb 2026

Ondaro Jon, Zúñiga-Elizari Jose Luis, Zufiría Mónica, Garciandia-Arcelus Maddi, Molleda Ángela Sánchez, Zulaica Miren, Lafarga Miguel, Riancho Javier, López de Munaín Adolfo, Moreno Fermin, Gil-Bea Francisco Javier, Gerenu Gorka

Abstract excerpt

Frontotemporal dementia (FTD) is a neurodegenerative disorder predominantly affecting individuals under 65 years of age, characterized by significant behavioral and language disabilities. Despite extensive research efforts, effective treatments for FTD remain elusive. Familial cases of FTD have been linked to genetic mutations in several key genes, among these, mutations in granulin (GRN) account for 5-20% of...

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Identifiers

PMID: 41677639
DOI: 10.3390/cells15030276
PMCID: PMC12897215

Genes

GRN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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Mitochondria and Lipid Defects in Hereditary Progranulin-Related Frontotemporal Dementia.PMID 41677639Read ↗

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Frontotemporal dementia as a consequence of GRN mutations: From disease cause to models to therapies.Semantic proximity Read ↗

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