Article

AmesNet: A Task-Conditioned Deep Learning Model with Enhanced Sensitivity and Generalization in Ames Mutagenicity Prediction

2025-03-25

Abstract excerpt

Regulatory agencies require comprehensive genotoxicity assessments for all novel small-molecule therapeutics prior to human trials. Developers often delay these studies until a candidate is nearing regulatory submission because they are expensive and secondary to bioactivity. This timing creates a bottleneck where late-stage failures can jeopardize >$10 million in capital and multiple years of developmental progre...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b4b0d801-8ffb-5dbd-8997-da52960d703d
DOI: 10.1101/2025.03.20.644379

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

AmesNet: A Task-Conditioned Deep Learning Model with Enhanced Sensitivity and Generalization in Ames Mutagenicity PredictionDOI 10.1101/2025.03.20.644379Read

DeepADR: Multi-modal Prediction of Adverse Drug Reaction Frequency by Integrating Early-Stage Drug Discovery Information via Kolmogorov-Arnold NetworksSemantic proximity Read

vToxiNet: a biologically constrained deep learning framework for interpretable prediction of drug-induced hepatotoxicitySemantic proximity Read

Artificial Intelligence uncovers carcinogenic human metabolitesSemantic proximity Read

A Deep-Learning Approach for Identifying Prospective Chemical HazardsSemantic proximity Read

Pre-trained molecular representations enable antimicrobial discoverySemantic proximity Read

Predictive Modeling of Multiplex Chemical Phenomics for Novel Cells and Patients: Applied to Personalized Alzheimer’s Disease Drug RepurposingSemantic proximity Read

AI for predicting chemical-effect associations at the chemical universe level – deepFPlearnSemantic proximity Read

A Machine Learning Approach Predicts Tissue-Specific Drug Adverse EventsSemantic proximity Read

It's difficult, but important, to make negative predictions.Semantic proximity Read

Fleming: An AI Agent for Antibiotic Design for Mycobacterium tuberculosisSemantic proximity Read

A Drug–Target Specificity Foundation Model for Off-target Prediction, Repurposing, and Generative DesignSemantic proximity Read

Unveiling Optimal Molecular Features for hERG Insights with Automatic Machine LearningSemantic proximity Read