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Article

It's difficult, but important, to make negative predictions.

Regulatory toxicology and pharmacology : RTP - 1 Apr 2016

Williams Richard V, Amberg Alexander, Brigo Alessandro, Coquin Laurence, Giddings Amanda, Glowienke Susanne, Greene Nigel, Jolly Robert, Kemper Ray, O'Leary-Steele Catherine, Parenty Alexis, Spirkl Hans-Peter, Stalford Susanne A, Weiner Sandy K, Wichard Joerg

Abstract excerpt

At the confluence of predictive and regulatory toxicologies, negative predictions may be the thin green line that prevents populations from being exposed to harm. Here, two novel approaches to making confident and robust negative in silico predictions for mutagenicity (as defined by the Ames test) have been evaluated. Analyses of 12 data sets containing >13,000 compounds, showed that negative predictivity is high...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26785392
DOI: 10.1016/j.yrtph.2016.01.008

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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