Article

A maternal-fetal PIEZO1 incompatibility as a barrier to Neanderthal-modern human admixture

2025-10-01

Abstract excerpt

When Neanderthals and anatomically modern humans interbred, they may have faced conditional reproductive barriers. We identify a likely maternal-fetal incompatibility involving a Neanderthal PIEZO1 gene variant predicted to increase red blood cell oxygen affinity. While potentially advantageous in Neanderthals, this trait became detrimental in hybrids: heterozygous mothers carrying one Neanderthal allele could del...

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Identifiers and source

Literature Corpus work: b4041fd7-ddf7-5ae1-88ef-415f19247271
DOI: 10.1101/2025.09.29.679417

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