Article

Targeting TRK: A Fast Tracked Application of Precision Oncology and Future Directions

2024-01-30

Abstract excerpt

The NTRK genes encode the tropomyosin-related receptor tyrosine kinases TrkA, TrkB and TrkC. TRK receptors play a critical role in the development of nervous system tissues during embryogenesis and early life. Recurrent genomic alterations in NTRK genes, typically fusions involving the 3′ region encoding the kinase domain juxtaposed to 5′ sequences from numerous partner genes, occur at a low frequency in a wide di...

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Literature Corpus work: f0d7f5aa-8f5a-582b-88b3-abee65bd2529
DOI: 10.22541/au.170664788.83890088/v1

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