Article

Diverse Cellular Tropisms and Immune Responses during Beta-Coronavirus Infections in Human Bronchial Epithelial Organoids

2023-10-12

Abstract excerpt

<title>Abstract</title> <p>The lower respiratory system serves as the primary target and barrier for beta-coronavirus (beta-CoV) infections. We investigated the interactions between four distinct beta-CoVs [HCoV-OC43, SARS-CoV, MERS-CoV, and SARS-CoV-2 (Omicron)] in human bronchial epithelial (HBE) organoids using single-cell RNA sequencing (scRNA-seq). Our findings revealed diverse viral tropisms: SARS-CoV and S...

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Literature Corpus work: b38eb7bb-cda5-559f-bf3f-24bd1e39f710
DOI: 10.21203/rs.3.rs-3391310/v1

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