Article

Aβ-HMGB1 complex is a pathogenic molecule at the advanced stage of Alzheimer’s disease

2025-06-15

Abstract excerpt

Multiple molecules including Aβ, tau and other inflammatory molecules mediate Alzheimer’s disease (AD) pathology. High mobility group box 1 (HMGB1), which is released from necrotic cells and binds to Toll-like receptors (TLRs) of surrounding neurons and microglia, also mediates AD pathology from the early stage. Paradoxically, HMGB1 concentration in cerebrospinal fluid (CSF) at the advanced stage of AD is not high...

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Literature Corpus work: b38d2f6f-771c-5aa1-8532-48912e86d58f
DOI: 10.1101/2025.06.12.659430

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