Article

Treatment of STEC infection via CRISPR-Cas targeted cleavage of the Shiga toxin gene in animal models

2025-02-28

Abstract excerpt

Escherichia coli is a ubiquitous gut commensal but also an opportunistic pathogen responsible for severe intestinal and extra-intestinal infections. Shiga toxin-producing E. coli (STEC) pose a significant public health threat, particularly in children, where infections can lead to bloody diarrhea and progress to hemolytic uremic syndrome (HUS), a life-threatening condition with long-term complications. Antibiotic...

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Literature Corpus work: b322d3e5-95be-5c9c-abeb-e09d2f2e5b99
DOI: 10.1101/2025.02.28.640725

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