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CRISPR Screen Reveals that EHEC's T3SS and Shiga Toxin Rely on Shared Host Factors for Infection.

mBio - 19 Jun 2018

Pacheco Alline R, Lazarus Jacob E, Sit Brandon, Schmieder Stefanie, Lencer Wayne I, Blondel Carlos J, Doench John G, Davis Brigid M, Waldor Matthew K

Abstract excerpt

Enterohemorrhagic Escherichia coli (EHEC) has two critical virulence factors-a type III secretion system (T3SS) and Shiga toxins (Stxs)-that are required for the pathogen to colonize the intestine and cause diarrheal disease. Here, we carried out a genome-wide CRISPR/Cas9 (clustered regularly interspaced short palindromic repeats with Cas9) loss-of-function screen to identify host loci that facilitate EHEC...

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Identifiers

PMID: 29921669
DOI: 10.1128/mBio.01003-18
PMCID: PMC6016243

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